Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy.

doi:10.1038/s41379-018-0038-2

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Article

Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2018

Matarraz Sergio, Leoz Pilar, Fernández Carlos, Colado Enrique, Chillón María Carmen, Vidriales María Belén, González Marcos, Rivera Daniel, Osuna Carlos Salvador, Caballero-Velázquez Teresa, Van Der Velden Vincent, Jongen-Lavrencic Mojca, Gutiérrez Oliver, Bermejo Ana Yeguas, Alonso Luis García, García Monique Bourgeois, De Ramón Sánchez Cristina, García-Donas Gloria, Mateo Aránzazu García, Recio Isabel, Sánchez-Real Javier, Mayado Andrea, Gutiérrez María Laura, Bárcena Paloma, Barrena Susana, López Antonio, Van Dongen Jacques, Orfao Alberto

Abstract excerpt

Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly...

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PMID: 29572500
DOI: 10.1038/s41379-018-0038-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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