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Article

Occurrence of neoplasms in individuals with congenital, severe GH deficiency from the Itabaianinha kindred.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Aug 2018

Marinho Cindi G, Mermejo Lívia M, Salvatori Roberto, Assirati João A, Oliveira Carla R P, Santos Elenilde G, Leal Ângela C G B, Barros-Oliveira Cynthia S, Damascena Nayra P, Lima Carlos A, Farias Catarine T, Moreira Ayrton C, Aguiar-Oliveira Manuel H

Abstract excerpt

Growth hormone (GH) and the insulin-like growth factor I (IGF-I) have cell proliferative and differentiation properties. Whether these hormones have a role in mutagenesis is unknown. Nevertheless, severe IGF-I deficiency seems to confer protection against the development of neoplasms. Here, we report five cases of adult patients with severe and congenital isolated GH deficiency (IGHD) due to the c.57+1G>A...

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Source

Identifiers

PMID: 29571594
DOI: 10.1016/j.ghir.2018.03.004

Genes

GHRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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