Article
Multi-regional sequencing reveals intratumor heterogeneity and positive selection of somatic mtDNA mutations in hepatocellular carcinoma and colorectal cancer.
International journal of cancer - 1 Sept 2018
Li Xin, Guo Xu, Li Deyang, Du Xiaohong, Yin Chun, Chen Cheng, Fang Wan, Bian Zhenyuan, Zhang Jing, Li Bingshan, Yang Hushan, Xing Jinliang
Abstract excerpt
Recent studies have revealed significant intratumor heterogeneity (ITH) of nuclear genome mutations and highlighted its function in tumor progression and treatment resistance. However, the ITH of somatic mitochondrial DNA (mtDNA) mutations detected in cancers remains unknown. In this study, we performed multiregional mtDNA sequencing of tumor and paratumor tissue samples from 12 hepatocellular carcinoma (HCC) and...
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