Article
Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2018
Dettling Steffen, Stamova Slava, Warta Rolf, Schnölzer Martina, Rapp Carmen, Rathinasamy Anchana, Reuss David, Pocha Kolja, Roesch Saskia, Jungk Christine, Warnken Uwe, Eckstein Volker, Grabe Niels, Schramm Christoph, Weigand Markus A, von Deimling Andreas, Unterberg Andreas, Beckhove Philipp, Herold-Mende Christel
Abstract excerpt
Purpose: Successful immunotherapies for IDHmut gliomas require better knowledge of T-cell target antigens. Here, we elucidated their antigen repertoire recognized by spontaneous T-cell responses using an unbiased proteomic approach.Experimental Design: Protein fractionations of tissue lysates from IDHmut gliomas (n = 4) were performed. Fractions were tested by IFNγ ELISpot assay for recognition through patients'...
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