KLK5, a novel potential suppressor of vaginal carcinogenesis.

Abstract excerpt

Vaginal cancer is rare and largely unexplored. We found here that kallikrein-related peptidase 5 (KLK5) is coordinately expressed along with other KLKs in all stratified epithelia, including vagina, pointing to potential role(s) in differentiation. Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to...

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• Share to Mice
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• Share to Apoptosis
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• Share to Tumor Suppressor Proteins