Article
Anaplastic Lymphoma Kinase Mutation (ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2018
Carneiro Benedito A, Pamarthy Sahithi, Shah Ami N, Sagar Vinay, Unno Kenji, Han HuiYing, Yang Ximing J, Costa Rubens B, Nagy Rebecca J, Lanman Richard B, Kuzel Timothy M, Ross Jeffrey S, Gay Laurie, Elvin Julia A, Ali Siraj M, Cristofanilli Massimo, Chae Young K, Giles Francis J, Abdulkadir Sarki A
Abstract excerpt
Purpose: Small cell carcinoma of the prostate (SCCP) is an aggressive disease that can arise de novo or by transdifferentiation from prostate adenocarcinoma. Alterations in anaplastic lymphoma kinase (ALK) gene are involved in neuroblastoma, lung cancer, and other malignancies, but its role in SCCP has not been documented. We describe a patient with refractory de novo SCCP with ALK F1174C-activating mutation who...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.