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Article

Network-based integration of multi-omics data for prioritizing cancer genes.

Bioinformatics (Oxford, England) - 15 Jul 2018

Dimitrakopoulos Christos, Hindupur Sravanth Kumar, Häfliger Luca, Behr Jonas, Montazeri Hesam, Hall Michael N, Beerenwinkel Niko

Abstract excerpt

Motivation: Several molecular events are known to be cancer-related, including genomic aberrations, hypermethylation of gene promoter regions and differential expression of microRNAs. These aberration events are very heterogeneous across tumors and it is poorly understood how they affect the molecular makeup of the cell, including the transcriptome and proteome. Protein interaction networks can help decode the...

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Identifiers

PMID: 29547932
DOI: 10.1093/bioinformatics/bty148
PMCID: PMC6041755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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