Article
[Familial Mediterranean fever as representative autoinflammatory disease].
Rinsho byori. The Japanese journal of clinical pathology - 1 Apr 2009
Yamazaki Kazuko, Yamazaki Takashi, Masumoto Junya, Suzuki Ayako, Yazaki Masahide, Agematsu Kazunaga
Abstract excerpt
Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fevers. FMF is an autosomal recessive disease that affects populations among non-Ashkenazi Jews, Arabs, Turks, and Armenians. Yet, it is observed worldwide, and approximately 90 FMF patients have been reported in Japan. FMF is caused by mutations in the MEFV gene, which encodes the pyrin protein. Pyrin protein is associated with the...
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