Article
Twenty years of molecular analyses in amyotrophic lateral sclerosis: genetic landscape of Italian patients.
Neurobiology of aging - 1 Jun 2018
Lamp Merit, Origone Paola, Geroldi Alessandro, Verdiani Simonetta, Gotta Fabio, Caponnetto Claudia, Devigili Grazia, Verriello Lorenzo, Scialò Carlo, Cabona Corrado, Canosa Antonio, Vanni Irene, Bellone Emilia, Eleopra Roberto, Mandich Paola
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a heterogeneous genetic background. Because mutation analysis by Sanger sequencing is costly and time-consuming, in recent years, next-generation sequencing (NGS) techniques have become of much interest. This study analyses the results of 20 years of molecular analyses in ALS patients in our laboratory using traditional methods and NGS....
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