Article
Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A.
Cardiovascular research - 1 Jun 2018
Barile Lucio, Cervio Elisabetta, Lionetti Vincenzo, Milano Giuseppina, Ciullo Alessandra, Biemmi Vanessa, Bolis Sara, Altomare Claudia, Matteucci Marco, Di Silvestre Dario, Brambilla Francesca, Fertig Tudor Emanuel, Torre Tiziano, Demertzis Stefanos, Mauri Pierluigi, Moccetti Tiziano, Vassalli Giuseppe
Abstract excerpt
Aims: Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have provided encouraging results. Exosomes, nanosized extracellular vesicles of endosomal origin, figure prominently in the bioactivities of these cells. However, a head-to-head comparison of exosomes from the two cell types has not been...
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