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Article

A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.

Skeletal muscle - 6 Mar 2018

Finno Carrie J, Gianino Giuliana, Perumbakkam Sudeep, Williams Zoë J, Bordbari Matthew H, Gardner Keri L, Burns Erin, Peng Sichong, Durward-Akhurst Sian A, Valberg Stephanie J

Abstract excerpt

BACKGROUND: The cause of immune-mediated myositis (IMM), characterized by recurrent, rapid-onset muscle atrophy in Quarter Horses (QH), is unknown. The histopathologic hallmark of IMM is lymphocytic infiltration of myofibers. The purpose of this study was to identify putative functional variants associated with equine IMM. METHODS: A genome-wide association (GWA) study was performed on 36 IMM QHs and 54 breed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Fibers, Skeletal

Share to Mutation, Missense

Share to Myosin Heavy Chains

Share to Myositis

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 29510741
DOI: 10.1186/s13395-018-0155-0
PMCID: PMC5838957

Genes

MYH1
MYH13
MYH2
MYH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.PMID 29510741Read ↗

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