Article
Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records.
Biological psychiatry - 15 Jun 2018
McCoy Thomas H, Castro Victor M, Hart Kamber L, Pellegrini Amelia M, Yu Sheng, Cai Tianxi, Perlis Roy H
Abstract excerpt
BACKGROUND: Genetic studies of neuropsychiatric disease strongly suggest an overlap in liability. There are growing efforts to characterize these diseases dimensionally rather than categorically, but the extent to which such dimensional models correspond to biology is unknown. METHODS: We applied a newly developed natural language processing method to extract five symptom dimensions based on the National...
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