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Article

'Cyclical Bias' in Microbiome Research Revealed by A Portable Germ-Free Housing System Using Nested Isolation.

Scientific reports - 28 Feb 2018

Rodriguez-Palacios Alexander, Aladyshkina Natalia, Ezeji Jessica C, Erkkila Hailey L, Conger Mathew, Ward John, Webster Joshua, Cominelli Fabio

Abstract excerpt

Germ-Free (GF) research has required highly technical pressurized HEPA-ventilation anchored systems for decades. Herein, we validated a GF system that can be easily implemented and portable using Nested Isolation (NesTiso). GF-standards can be achieved housing mice in non-HEPA-static cages, which only need to be nested 'one-cage-inside-another' resembling 'Russian dolls'. After 2 years of monitoring ~100,000...

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Identifiers

PMID: 29491439
DOI: 10.1038/s41598-018-20742-1
PMCID: PMC5830500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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