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Dermaseptin-S1 decreasesCandida albicansgrowth, biofilm formation and the expression of hyphal wall protein 1 and aspartic protease genes

24 Feb 2018

Abstract excerpt

AIMS: This study aimed to investigate the effect of synthetic antimicrobial peptide dermaseptin-S1 (DS1) (ALWKTMLKKLGTMALHAGKAALGAADTISQGTQ) on the growth of Candida albicans, its transition from blastospore to hyphae, and its biofilm formation. We also analysed the expression of different genes (HWP1 and SAPs) involved in C. albicans virulence. METHODS AND RESULTS: Using cell count we showed that in addition to...

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PMID: 29476689
DOI: 10.1111/jam.13745

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