Article
Diagnostic utility of telomere length testing in a hospital-based setting.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2018
Alder Jonathan K, Hanumanthu Vidya Sagar, Strong Margaret A, DeZern Amy E, Stanley Susan E, Takemoto Clifford M, Danilova Ludmila, Applegate Carolyn D, Bolton Stephen G, Mohr David W, Brodsky Robert A, Casella James F, Greider Carol W, Jackson J Brooks, Armanios Mary
Abstract excerpt
Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic utility of TL measurement in clinical settings is not fully known. We tested the value of TL measurement by flow cytometry and FISH (flowFISH) in patients with mutations in telomerase and telomere maintenance genes. TL had a discrete and reproducible normal range with definable upper and lower boundaries. While TL above the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.