Article
Traumatic stress and accelerated DNA methylation age: A meta-analysis.
Psychoneuroendocrinology - 1 Jun 2018
Wolf Erika J, Maniates Hannah, Nugent Nicole, Maihofer Adam X, Armstrong Don, Ratanatharathorn Andrew, Ashley-Koch Allison E, Garrett Melanie, Kimbrel Nathan A, Lori Adriana, Va Mid-Atlantic Mirecc Workgroup, Aiello Allison E, Baker Dewleen G, Beckham Jean C, Boks Marco P, Galea Sandro, Geuze Elbert, Hauser Michael A, Kessler Ronald C, Koenen Karestan C, Miller Mark W, Ressler Kerry J, Risbrough Victoria, Rutten Bart P F, Stein Murray B, Ursano Robert J, Vermetten Eric, Vinkers Christiaan H, Uddin Monica, Smith Alicia K, Nievergelt Caroline M, Logue Mark W
Abstract excerpt
BACKGROUND: Recent studies examining the association between posttraumatic stress disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of cellular age that exceed chronological age, have yielded mixed results. METHODS: We conducted a meta-analysis of trauma exposure and PTSD diagnosis and symptom severity in association with accelerated DNA methylation age using data from 9 cohorts...
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