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Autoregulation and Virulence Control by the Toxin-Antitoxin System SavRS in Staphylococcus aureus

7 Feb 2018

Abstract excerpt

ABSTRACT Toxin-antitoxin (TA) systems play diverse physiological roles, such as plasmid maintenance, growth control, and persister cell formation, but their involvement in bacterial pathogenicity remains largely unknown. Here, we have identified a novel type II toxin-antitoxin system, SavRS, and revealed the molecular mechanisms of its autoregulation and virulence control in Staphylococcus aureus ....

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PMID: 29440365
DOI: 10.1128/iai.00032-18

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