Article
Acute Drug Effects on the Human Placental Tissue: The Development of a Placental Murine Xenograft Model.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2018
Verheecke Magali, Hermans Els, Tuyaerts Sandra, Souche Erika, Van Bree Rita, Verbist Godelieve, Everaert Tina, Cortès-Calabuig Alvaro, Van Houdt Jeroen, Van Calsteren Kristel, Amant Frederic
Abstract excerpt
OBJECTIVE: A pilot study was conducted to establish a human placental xenograft, which could serve as a model to evaluate the effect of toxic exposures during pregnancy. STUDY DESIGN: The protocol consisted of engraftment of third-trimester human placental tissue in immunocompromised mice, after induction of a pseudo-pregnancy state by ovariectomy and progesterone supplementation. To validate the model, the...
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