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Article

Selective cognitive impairment and hyposmia in p.A53T SNCA PD vs typical PD.

Neurology - 6 Mar 2018

Koros Christos, Stamelou Maria, Simitsi Athina, Beratis Ion, Papadimitriou Dimitra, Papagiannakis Nikolaos, Fragkiadaki Stella, Kontaxopoulou Dionysia, Papageorgiou Sokratis G, Stefanis Leonidas

Abstract excerpt

OBJECTIVE: To evaluate nonmotor symptoms in early SNCA/p.A53T Parkinson disease (PD) (A53T PD) compared to typical PD (tPD). METHODS: The presence of hyposmia, neuropsychiatric, dysautonomic, and sleep disturbances was assessed by standardized questionnaires and validated scales in 18 patients with A53T PD and 18 patients with tPD, matched for age, sex, and disease duration. All patients were enrolled into the...

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PMID: 29438043
DOI: 10.1212/WNL.0000000000005063

Genes

SNCA

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