Drosophila tafazzin mutants have impaired exercise capacity.

Abstract excerpt

Cardiolipin (CL) is a mitochondrial phospholipid that helps maintain normal structure of the inner mitochondrial membrane and stabilize the protein complexes of the electron transport chain to promote efficient ATP synthesis. Tafazzin, an acyl-transferase, is required for synthesis of the mature form of CL. Mutations in the tafazzin (TAZ) gene are associated with a human disorder known as Barth syndrome. Symptoms...

Topics

• 1-Acylglycerophosphocholine O-Acyltransferase
• Animals
• Drosophila
• Drosophila Proteins
• Motor Neurons
• Muscle, Skeletal
• Mutation
• Physical Conditioning, Animal