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Article

Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.

Annals of neurology - 1 Mar 2018

Dazzo Emanuela, Rehberg Kati, Michelucci Roberto, Passarelli Daniela, Boniver Clementina, Vianello Dri Valeria, Striano Pasquale, Striano Salvatore, Pasterkamp R Jeroen, Nobile Carlo

Abstract excerpt

OBJECTIVE: Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families remain genetically unsolved, and the underlying molecular mechanisms are yet to be clarified. We aimed to identify additional genes causing ADLTE to better...

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Source

Identifiers

PMID: 29394500
DOI: 10.1002/ana.25167

Genes

LGI1
RELN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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