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Article

Preimplantation Genetic Diagnosis of Multiple Endocrine Neoplasia Type 2A Using Informative Markers Identified by Targeted Sequencing.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2018

Chen Songchang, Li Shuyuan, Zhang Junyu, Zhang Lanlan, Chen Yiyao, Wang Li, Jin Li, Hu Yuting, Qi Xiaoping, Huang Hefeng, Xu Chenming

Abstract excerpt

BACKGROUND: The revised guidelines for the management of medullary thyroid carcinoma recommend that genetic counseling regarding reproductive options, including preimplantation genetic diagnosis (PGD), be considered for all RET mutation carriers of reproductive age to avoid the transmission of multiple endocrine neoplasia type 2 (MEN2). However, the high complexity and cost of PGD have hindered its widespread...

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PMID: 29378479
DOI: 10.1089/thy.2017.0200

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PGD
RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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