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RUNX1 Mutations in Inherited and Sporadic Leukemia

20 Dec 2017

Abstract excerpt

RUNX1 is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). In sporadic AML, mutations in RUNX1 are usually secondary events, whereas in FPD/AML they are initiating events. Here we will describe mutations in RUNX1 in sporadic AML and in FPD/AML, discuss the mechanisms...

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PMID: 29326930
DOI: 10.3389/fcell.2017.00111

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