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Ultra-Sensitive Droplet Digital PCR for the Assessment of Microchimerism in Cellular Therapies

2 Jan 2018

Abstract excerpt

Current techniques to assess chimerism after hematopoietic stem cell transplantation (HSCT) are limited in both sensitivity and precision. These drawbacks are problematic in the context of cellular therapies that frequently result in microchimerism (donor chimerism <1%). We have developed a highly sensitive droplet digital PCR (ddPCR) assay using commercially available regents with good performance throughout the...

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PMID: 29305193
DOI: 10.1016/j.bbmt.2017.12.802

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