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Article

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B.

Virus research - 15 Feb 2018

Giraldo Maria Isabel, Vargas-Cuartas Oscar, Gallego-Gomez Juan Carlos, Shi Pei-Yong, Padilla-Sanabria Leonardo, Castaño-Osorio Jhon Carlos, Rajsbaum Ricardo

Abstract excerpt

Dengue virus (DENV) is a member of the Flaviviridae family, which is transmitted to mammalian species through arthropods, and causes dengue fever or severe dengue fever in humans. The DENV genome encodes for multiple nonstructural (NS) proteins including NS1. NS1 plays an essential role in replication by interacting with other viral proteins including NS4B, however how these interactions are regulated during...

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Identifiers

PMID: 29294313
DOI: 10.1016/j.virusres.2017.12.013
PMCID: PMC5811335

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