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Article

In silico VHL Gene Mutation Analysis and Prognosis of Pancreatic Neuroendocrine Tumors in von Hippel-Lindau Disease.

The Journal of clinical endocrinology and metabolism - 1 Apr 2018

Tirosh Amit, El Lakis Mustapha, Green Patience, Nockel Pavel, Patel Dhaval, Nilubol Naris, Gara Sudheer Kumar, Keutgen Xavier M, Linehan W Marston, Kebebew Electron

Abstract excerpt

Context: Patients with von Hippel-Lindau (vHL) disease caused by a missense VHL mutation have a more severe phenotype compared with other VHL mutation types. Objective: To define pancreatic neuroendocrine tumor (PNET) aggressiveness according to VHL genotype. Design: A prospective natural history study. Setting: The National Institutes of Health clinical center. Patients: Patients with vHL disease, pancreatic...

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Source

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Identifiers

PMID: 29294023
DOI: 10.1210/jc.2017-02434
PMCID: PMC6276699

Genes

VHL
HPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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