Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

doi:10.1158/1078-0432.CCR-17-2994

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Article

Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2018

Aung Kyaw L, Fischer Sandra E, Denroche Robert E, Jang Gun-Ho, Dodd Anna, Creighton Sean, Southwood Bernadette, Liang Sheng-Ben, Chadwick Dianne, Zhang Amy, O'Kane Grainne M, Albaba Hamzeh, Moura Shari, Grant Robert C, Miller Jessica K, Mbabaali Faridah, Pasternack Danielle, Lungu Ilinca M, Bartlett John M S, Ghai Sangeet, Lemire Mathieu, Holter Spring, Connor Ashton A, Moffitt Richard A, Yeh Jen Jen, Timms Lee, Krzyzanowski Paul M, Dhani Neesha, Hedley David, Notta Faiyaz, Wilson Julie M, Moore Malcolm J, Gallinger Steven, Knox Jennifer J

Abstract excerpt

Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational and transcriptional features for better treatment selection.Experimental Design: Patients with advanced PDAC were prospectively recruited prior to first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided...

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PMID: 29288237
DOI: 10.1158/1078-0432.CCR-17-2994
PMCID: PMC5968824

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