Article
Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2018
Grybchuk Danyil, Akopyants Natalia S, Kostygov Alexei Y, Konovalovas Aleksandras, Lye Lon-Fye, Dobson Deborah E, Zangger Haroun, Fasel Nicolas, Butenko Anzhelika, Frolov Alexander O, Votýpka Jan, d'Avila-Levy Claudia M, Kulich Pavel, Moravcová Jana, Plevka Pavel, Rogozin Igor B, Serva Saulius, Lukeš Julius, Beverley Stephen M, Yurchenko Vyacheslav
Abstract excerpt
Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored. We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite Leishmania (Crithidia and Leptomonas), as well as plant-infecting PhytomonasLeptomonas pyrrhocoris was a hotbed for viral discovery, carrying a virus (Leptomonas pyrrhocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase...
Topics
- Animals
- Euglenozoa Infections
- Genetic Variation
- Host Specificity
- Host-Pathogen Interactions
- Humans
- Phylogeny
- RNA Viruses