Article
Auxin molecular field maps define AUX1 selectivity: many auxin herbicides are not substrates.
The New phytologist - 1 Mar 2018
Hoyerova Klara, Hosek Petr, Quareshy Mussa, Li Jun, Klima Petr, Kubes Martin, Yemm Antony A, Neve Paul, Tripathi Ashutosh, Bennett Malcolm J, Napier Richard M
Abstract excerpt
Developmental responses to auxin are regulated by facilitated uptake and efflux, but detailed molecular understanding of the carrier proteins is incomplete. We have used pharmacological tools to explore the chemical space that defines substrate preferences for the auxin uptake carrier AUX1. Total and partial loss-of-function aux1 mutants were assessed against wild-type for dose-dependent resistance to a range of...
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