Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients

1 Dec 2017

Abstract excerpt

BACKGROUND: The HER2-HER3 heterodimer significantly decreases survival in breast cancer patients. However, the prognostic value of HER2-HER3 overexpression remains unknown in gastric cancer (GC). METHODS: The expression levels of HER2, HER3, Akt, p-Akt, mTOR and p-mTOR were examined in specimens from 120 GC patients by immunohistochemistry and quantitative reverse transcription-PCR. The associations of HER...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastric Cancer Management and Outcomes
Share to HER2/EGFR in Cancer Research
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29233126
DOI: 10.1186/s12885-017-3851-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patientsPMID 29233126Read ↗

HER2 expression and PI3K-Akt pathway alterations in gastric cancer.Semantic proximity Read ↗

Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancerSemantic proximity Read ↗

Molecular target: pan-AKT in gastric cancerSemantic proximity Read ↗

Genomic Profiling of HER2-Positive Gastric Cancer: PI3K/Akt/mTOR Pathway as Predictor of Outcomes in HER2-Positive Advanced Gastric Cancer Treated with TrastuzumabSemantic proximity Read ↗

HER2/PI3K/AKT pathway in HER2-positive breast cancer: A reviewSemantic proximity Read ↗

Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression AnalysisSemantic proximity Read ↗

Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancerSemantic proximity Read ↗

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review.Semantic proximity Read ↗

Prognostic Implications of Altered Human Epidermal Growth Factor Receptors (HERs) in Gastric Carcinomas: HER2 and HER3 Are Predictors of Poor OutcomeSemantic proximity Read ↗

Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survivalSemantic proximity Read ↗

Differential gene expression and AKT targeting in triple negative breast cancerSemantic proximity Read ↗

<i>TNK</i><i>2</i> gene amplification is a novel predictor of a poor prognosis in patients with gastric cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.