Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.

doi:10.1099/mgen.0.000138

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Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.

Microbial genomics - 1 Nov 2017

Lilje Berit, Rasmussen Rasmus Vedby, Dahl Anders, Stegger Marc, Skov Robert Leo, Fowler Vance G, Ng Kim Lee, Kiil Kristoffer, Larsen Anders Rhod, Petersen Andreas, Johansen Helle Krogh, Schønheyder Henrik Carl, Arpi Magnus, Rosenvinge Flemming S, Korup Eva, Høst Ulla, Hassager Christian, Gill Sabine Ute Alice, Hansen Thomas Fritz, Johannesen Thor Bech, Smit Jesper, Søgaard Peter, Skytt Andersen Paal, Eske-Bruun Niels

Abstract excerpt

Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was...

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PMID: 29208121
DOI: 10.1099/mgen.0.000138
PMCID: PMC5729915

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