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Article

Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer.

Cancer letters - 28 Feb 2018

Yang Zongyuan, Jin Ping, Xu Sen, Zhang Taoran, Yang Xin, Li Xiaoting, Wei Xiao, Sun Chaoyang, Chen Gang, Ma Ding, Gao Qinglei

Abstract excerpt

Inflammation and host stromal activation contribute significantly to ovarian cancer (OC) initiation and malignant progression. However, the complex reciprocal interactions between them are largely unknown. Here, we discovered that the tumor suppressor gene Dicer was paradoxically overexpressed in ovarian tumor stroma, and induced fibroblast activation and stromal inflammation. Dicer transformed normal fibroblasts...

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Source

Identifiers

PMID: 29199004
DOI: 10.1016/j.canlet.2017.11.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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