Article
Payload hardware and experimental protocol development to enable future testing of the effect of space microgravity on the resistance to gentamicin of uropathogenic Escherichia coli and its σs-deficient mutant.
Life sciences in space research - 1 Nov 2017
Matin A C, Wang J-H, Keyhan Mimi, Singh Rachna, Benoit Michael, Parra Macarena P, Padgen Michael R, Ricco Antonio J, Chin Matthew, Friedericks Charlie R, Chinn Tori N, Cohen Aaron, Henschke Michael B, Snyder Timothy V, Lera Matthew P, Ross Shannon S, Mayberry Christina M, Choi Sungshin, Wu Diana T, Tan Ming X, Boone Travis D, Beasley Christopher C, Piccini Matthew E, Spremo Stevan M
Abstract excerpt
Human immune response is compromised and bacteria can become more antibiotic resistant in space microgravity (MG). We report that under low-shear modeled microgravity (LSMMG), stationary-phase uropathogenic Escherichia coli (UPEC) become more resistant to gentamicin (Gm), and that this increase is dependent on the presence of σs (a transcription regulator encoded by the rpoS gene). UPEC causes urinary tract...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.