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Article

Ectopic Expression of PCSK9 by Smooth Muscle Cells Contributes to Aortic Dissection.

Annals of vascular surgery - 1 Apr 2018

Iida Yasunori, Tanaka Hiroki, Sano Hideto, Suzuki Yuko, Shimizu Hideyuki, Urano Tetsumei

Abstract excerpt

BACKGROUND: Acute aortic dissection (AAD) is a common disease among the elderly. Although several risk factors of AAD have been reported, the molecular mechanism underlying AAD development remains to be elucidated. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases low-density lipoprotein cholesterol levels in blood by preventing its clearance. Therefore, PCSK9 inhibition is a promising therapeutic...

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Topics

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Share to Aorta, Abdominal
Share to Aortic Aneurysm
Share to Aortic Dissection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout, ApoE

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Share to Proprotein Convertase 9

Share to Vascular Calcification

Source

Identifiers

PMID: 29197601
DOI: 10.1016/j.avsg.2017.10.005

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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