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Article

Inhibition of Retrograde Transport Limits Polyomavirus Infection In Vivo

16 Nov 2017

Abstract excerpt

PyVs can cause significant morbidity and mortality in immunocompromised individuals. No clinically efficacious anti-PyV therapeutic agents are available. A recently identified inhibitor of retrograde transport, Retro-2 cycl , blocks movement of PyV virion-containing vesicles from early endosomes to the endoplasmic reticulum, an early step in the PyV life cycle. Retro-2 cycl and its derivatives have been shown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29152583
DOI: 10.1128/mspheredirect.00494-17

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