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Article

Position-Specific contribution of interface tryptophans on membrane protein energetics.

Biochimica et biophysica acta. Biomembranes - 1 Feb 2018

Chaturvedi Deepti, Mahalakshmi Radhakrishnan

Abstract excerpt

Interface tryptophans are key residues that facilitate the folding and stability of membrane proteins. Escherichia coli OmpX possesses two unique interface tryptophans, namely Trp76, which is present at the interface and is solvent-exposed, and Trp140, which is relatively more lipid solvated than Trp76 in symmetric lipid membranes. Here, we address the requirement for tryptophan and the consequences of aromatic...

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PMID: 29128310
DOI: 10.1016/j.bbamem.2017.11.003
PMCID: PMC7115948

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