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Article

Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency.

PloS one - 1 Jan 2017

Rannou Fabrice, Scotet Virginie, Marcorelles Pascale, Monnoyer Roxane, Le Maréchal Cédric

Abstract excerpt

PURPOSE: Current evidence indicates that the common AMPD1 gene variant is associated with improved survival in patients with advanced heart failure. Whilst adenosine has been recognized to mediate the cardioprotective effect of C34T AMPD1, the precise pathophysiologic mechanism involved remains undefined to date. To address this issue, we used cardio-pulmonary exercise testing data (CPX) from subjects with...

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Identifiers

PMID: 29095874
DOI: 10.1371/journal.pone.0187266
PMCID: PMC5667816

Genes

AMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency.PMID 29095874Read ↗

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