Prevalence of gag mutations associated with in vitro resistance to capsid inhibitor GS-CA1 in HIV-1 antiretroviral-naive patients

Abstract excerpt

Sir, HIV capsid (CA) plays an essential role in multiple stages of the viral replication cycle, but it remains an unexplored target for ART. Previous in vitro studies have described a novel class of exquisitely potent and metabolically stable HIV capsid inhibitors (CAIs).1 Recently, preclinical studies have revealed a highly potent CAI, GS-CA1, with an EC50 of 140 pM, which is active against all major HIV-1 group...

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