Article
Genomic Characterization of Chromosomal Insertions: Insights into the Mechanisms Underlying Chromothripsis.
Cytogenetic and genome research - 1 Jan 2017
Kato Takema, Ouchi Yuya, Inagaki Hidehito, Makita Yoshio, Mizuno Seiji, Kajita Mitsuharu, Ikeda Toshiro, Takeuchi Kazuhiro, Kurahashi Hiroki
Abstract excerpt
Chromosomal insertions are rare structural rearrangements, and the molecular mechanisms underlying their origin are unknown. In this study, we used whole genome sequencing to analyze breakpoints and junction sequences in 4 patients with chromosomal insertions. Our analysis revealed that none of the 4 cases involved a simple insertion mediated by a 3-chromosomal breakage and rejoining events. The inserted...
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