Article
Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus.
PloS one - 1 Jan 2017
Levitz Ruth, Gao Yajing, Dozmorov Igor, Song Ran, Wakeland Edward K, Kahn Jeffrey S
Abstract excerpt
Respiratory syncytial virus (RSV) is a major respiratory pathogen of infants and young children. Multiple strains of both subgroup A and B viruses circulate during each seasonal epidemic. Genetic heterogeneity among RSV genomes, in large part due to the error prone RNA-dependent, RNA polymerase, could mediate variations in pathogenicity. We evaluated clinical strains of RSV for their ability to induce the innate...
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