Article
Human Genome Sequencing at the Population Scale: A Primer on High-Throughput DNA Sequencing and Analysis.
American journal of epidemiology - 15 Oct 2017
Goldfeder Rachel L, Wall Dennis P, Khoury Muin J, Ioannidis John P A, Ashley Euan A
Abstract excerpt
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then...
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