Article
Predicting metabolic adaptation from networks of mutational paths.
Nature communications - 25 Sept 2017
Josephides Christos, Swain Peter S
Abstract excerpt
Competition for substrates is a ubiquitous selection pressure faced by microbes, yet intracellular trade-offs can prevent cells from metabolizing every type of available substrate. Adaptive evolution is constrained by these trade-offs, but their consequences for the repeatability and predictability of evolution are unclear. Here we develop an eco-evolutionary model with a metabolic trade-off to generate networks...
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