Article
The Association of Polymorphisms in the Gene Encoding Gonadotropin-Releasing Hormone with Serum Testosterone Level during Androgen Deprivation Therapy and Prognosis of Metastatic Prostate Cancer.
The Journal of urology - 1 Mar 2018
Shiota Masaki, Fujimoto Naohiro, Takeuchi Ario, Kashiwagi Eiji, Dejima Takashi, Inokuchi Junichi, Tatsugami Katsunori, Yokomizo Akira, Kajioka Shunichi, Uchiumi Takeshi, Eto Masatoshi
Abstract excerpt
PURPOSE: Serum testosterone suppression during androgen deprivation therapy has been reported to affect the efficacy of androgen deprivation therapy. However, the factors impacting hormonal variations during androgen deprivation therapy remain unclear. Therefore, in this study we investigated the significance of missense polymorphisms in the gene encoding GNRH in men treated with primary androgen deprivation...
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