Article
The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Development (Cambridge, England) - 15 Oct 2017
Paikari Alireza, D Belair Cassandra, Saw Daniel, Blelloch Robert
Abstract excerpt
The vertebrate-specific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302. The miR-302 locus is found broadly among vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria, suggesting a role in placental development. Here, we evaluate that role. A knock-in reporter for the mouse miR-290 cluster is expressed throughout the embryo until gastrulation, when it...
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