Article
Variations in glycoprotein B contribute to immunogenic difference between PRV variant JS-2012 and Bartha-K61.
Veterinary microbiology - 1 Sept 2017
Yu Zhi-Qing, Tong Wu, Zheng Hao, Li Li-Wei, Li Guo-Xin, Gao Fei, Wang Tao, Liang Chao, Ye Chao, Wu Ji-Qiang, Huang Qinfeng, Tong Guang-Zhi
Abstract excerpt
A newly emerged pseudorabies virus (PRV) variant has been identified in many Bartha-K61-vaccinated pig farms. This variant has caused great economic losses to the swine industry in China since 2011. Sequence analysis demonstrated that the gB gene of the emerging PRV variant JS-2012 had multiple variations compared with the vaccine strain Bartha-K61. In the study, a specific CRISPR/Cas9 system combined with...
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