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Article

In vivo assessment of muscle membrane properties in the sodium channel myotonias

6 Sept 2017

Abstract excerpt

INTRODUCTION: The gain-of-function mutations that underlie sodium channel myotonia (SCM) and paramyotonia congenital (PMC) produce differing clinical phenotypes. We used muscle velocity recovery cycles (MVRCs) to investigate membrane properties. METHODS: MVRCs and responses to trains of stimuli were compared in patients with SCM (n = 9), PMC (n = 8), and normal controls (n = 26). RESULTS: The muscle relative...

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PMID: 28877545
DOI: 10.1002/mus.25956

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