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Article

MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes.

Leukemia & lymphoma - 1 Jun 2018

Raess Philipp W, Moore Stephen R, Cascio Michael J, Dunlap Jennifer, Fan Guang, Gatter Ken, Olson Susan B, Braziel Rita M

Abstract excerpt

Accurate subclassification of aggressive B cell lymphomas (ABCLs) requires integration of morphologic, immunohistochemical (IHC), and cytogenetic information. Optimal strategies have not been well defined for diagnosis of high grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBLwR) and double expressor lymphomas with MYC and BCL2 protein overexpression. One hundred and eighty seven ABCLs were...

Topics

Biomarkers, Tumor
Cytogenetic Analysis
Gene Expression
Genetic Variation
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Ki-67 Antigen
Lymphoma, B-Cell
Neoplasm Grading

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Proto-Oncogene Proteins c-myc

Reproducibility of Results

Source

Identifiers

PMID: 28868942
DOI: 10.1080/10428194.2017.1370547

Genes

MYC
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes.PMID 28868942Read ↗

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