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Article

Clinical experience using intranasal ketamine in the longitudinal treatment of juvenile bipolar disorder with fear of harm phenotype.

Journal of affective disorders - 1 Jan 2018

Papolos Demitri, Frei Mark, Rossignol Daniel, Mattis Steven, Hernandez-Garcia Laura C, Teicher Martin H

Abstract excerpt

OBJECTIVES: Fear of Harm (FOH) is a pediatric onset phenotype of bipolar disorder (BD) characterized by BD plus treatment resistance, separation anxiety, aggressive obsessions, parasomnias, and thermal dysregulation. Intranasal ketamine (InK) in 12 youths with BD-FOH produced marked improvement during a two-week trial. Here we report on the open effectiveness and safety of InK in maintenance treatment of BD-FOH...

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Identifiers

PMID: 28866299
DOI: 10.1016/j.jad.2017.08.081

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