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Article

Analysis and functional characterization of sequence variations in ligand binding domain of thyroid hormone receptors in autism spectrum disorder (ASD) patients.

Autism research : official journal of the International Society for Autism Research - 1 Dec 2017

Kalikiri Mahesh Kumar, Mamidala Madhu Poornima, Rao Ananth N, Rajesh Vidya

Abstract excerpt

Autism spectrum disorder (ASD) is a neuro developmental disorder, reported to be on a rise in the past two decades. Thyroid hormone-T3 plays an important role in early embryonic and central nervous system development. T3 mediates its function by binding to thyroid hormone receptors, TRα and TRβ. Alterations in T3 levels and thyroid receptor mutations have been earlier implicated in neuropsychiatric disorders and...

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Identifiers

PMID: 28856816
DOI: 10.1002/aur.1838

Genes

THRA
THRB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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