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Article

Gene Disrupting Mutations Associated with Regression in Autism Spectrum Disorder.

Journal of autism and developmental disorders - 1 Nov 2017

Goin-Kochel Robin P, Trinh Sandy, Barber Shelley, Bernier Raphael

Abstract excerpt

Approximately one-third of children with autism spectrum disorder (ASD) reportedly lose skills within the first 3 years, yet a causal mechanism remains elusive. Considering evidence of strong genetic effects for ASD and findings that distinct phenotypes in ASD associate with specific genetic events, we examined rates of parent-reported regression in the Simons Simplex Collection with likely gene disrupting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28856484
DOI: 10.1007/s10803-017-3256-4
PMCID: PMC5693665

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